Draft
An Evidence Based Review of Needle Exchange Programs

Forward
Needle/syringe exchange programs (NEP) were developed 20 years ago in the Netherlands in the face of the soaring incidence of Human Immunodeficiency Virus (HIV) infection among addicts who injected their drugs (IDU). Since then similar programs have been developed in other countries around the world where injecting drug use and HIV co-exist as serious problems. The first NEPs in the United States were established on the west coast in Tacoma, Portland, San Francisco, and in New York City in the late 1980’s. By 1997, 10 years later, there were 113 programs in more than 30 states. The European Union is currently planning massive increases in needle exchange and methadone services along with expanded condom distribution in an attempt to better control the growing HIV epidemic among member states.
These programs, some operating illegally, continue to be controversial. The rationale for needle exchange is simple; if the injection drug users had access to clean needles and syringes and would use them consistently without sharing them, the chain of HIV transmission from person to person through needle sharing would be broken. Although this is an attractive idea, the effectiveness of these programs has been difficult to evaluate.
A review of the reports published in the literature from 1994 through mid-2003 was conducted to determine whether the widely proclaimed success of NEPs in preventing or reducing HIV transmission among IDUs was supportable with “hard” data. A search of Medline on the National Library of Medicine’s web-site for journal articles published after Jan.1, 1994 on needle/syringe exchange programs yielded hundreds of citations. Editorials, letters, news items and review articles were excluded in the selection process. Further exclusion of other articles that lacked abstracts revealed few cohort studies of NEPs whose design and results might allow evaluation of their efficacy in reducing HIV transmission. Data on the hepatitis viruses, Hepatitis B (HBV), and Hepatitis C (HCV), were considered surrogates for HIV when incorporated into an NEP study. Those selected should have been able to show differences in viral seroprevalence between users of needle/syringe exchange and non-users, reduction in viral incidence, or show differences in an endpoint such as mortality. At the time of most of these studies it was thought that risky injection behavior such as needle sharing was the principle route of HIV transmission among IDUs. Now, however, high-risk sexual behavior is recognized to be equally, if not more, important. It is reasonable to assume, nevertheless, that NEPs should confer some measurable protective effect at least if the participants use them regularly and avoid risky injection practices.
Seven reports out of the total were identified which by design might provide a credible measure of the effectiveness of NEPs in preventing or reducing HIV, HBV, or HCV transmission among IDUs.

Epidemiological Studies
Researchers in Montreal studied a cohort of nearly 1600 needle-exchange participants for an average of 21.7 months (1). The study revealed 89 incident cases of HIV infection with a seroconversion probability of 33 percent among needle exchange users and 13 percent among non-users. The case-control study suggested that consistent needle exchange use continued to be associated with HIV seroconversions during follow-up. Despite adjustments for confounders, the researchers noted that HIV risk elevations related to needle exchange remained both substantial and consistent in their cohort of intravenous drug users.
Results from a Vancouver study failed to show a measurable beneficial effect of their needle exchange program on an on-going HIV epidemic among IDUs (2). Instead, participation in the NEP was a predictor, along with other variables, for HIV seropositivity. This happened in spite of the fact that the program was the largest NEP in North America.
This study was re-examined later to determine whether the NEP itself was responsible for the increased spread of HIV among participants (3). The re-examination of the data showed that this was unlikely and due, in part, to the age (young), drug injected (cocaine), and sex trade among frequent attendees who seroconverted during the study period. The data, of course, did not indicate any effect of the NEP on HIV transmission during the outbreak.
Looking back now, it appears likely that many if not most of the infections during the on-going epidemic were the result of sexual transmission rather than needle sharing.
A study was reported which measured the impact of HIV and other risk factors on mortality in a cohort of IDUs and non-injecting drug users in Amsterdam (4). The participants were recruited between 1985 and 1992 and followed up through 1993. A total of 77 deaths occurred among the 632 participants during the study period. The death rate among HIV positive IDU was 3.5 times higher than among HIV negative IDU and 8 times higher than among HIV negative non-injecting drug users. When data were analyzed only for IDUs neither the daily use of methadone nor participation in needle and syringe exchange programs were associated with lower mortality.
Another report from Amsterdam involved prospective studies of a cohort of 582 HIV-negative drug users in a harm reduction program that included high dose methadone maintenance, needle exchange, counseling and HIV testing (5). The authors stated that in this setting, methadone use and needle exchange did not reduce the spread of HIV. During 1906 person-years 58 of the 582 drug injectors became infected with HIV.
A study of needle exchange programs in Seattle found no protective effect of needle/syringe exchange on the transmission of HBV or HCV among participants (6). The highest incidence of infection with both viruses occurred among current users of the exchange. The authors stated that the goal of elimination or substantial reduction in risk behavior that may transmit HIV among IDUs had not been achieved. Risk behavior for HBV and HCV transmission were still practiced by a substantial proportion of Seattle area drug injectors.
The virological efficacy of a needle exchange program in Sweden was evaluated in a cohort study (7). Transmission of HBV, HCV and HIV was measured among 698 IDU’s Despite free syringes and needles, both HBV and HCV continued to spread at high rates during the study. During a median time of 31 months, however, no spread of HIV was observed. The authors observed that the low HIV prevalence at baseline, 2.5 %, might have been partly responsible for this. While these results could be interpreted as showing the effectiveness of needle exchange programs in preventing or reducing the spread of HIV in IDU populations with low HIV prevalence, the rapid spread of both HBV and HCV during this study casts doubt on the role of needle exchange in limiting the spread of HIV.
The results of a 10-year study of initially HIV negative male and female IDUs in Baltimore were published recently (8). Study participants included 1447 males and 427 females. The participants were primarily African American (91%) with a median age at entry of 35 years. The median duration of injecting drug use at enrollment was 14 years. Younger age (less than 30) was an independent predictor of seroconversion among both men and women. Significantly higher HIV incidence was seen among participants of both sexes who injected cocaine alone or in combination with other drugs. Among male participants less than a high school education, needle sharing with multiple partners, daily injection and shooting gallery attendance were all independent predictors of HIV seroconversion. The incidence of HIV was double for men who recently engaged in homosexual activity and cocaine injection. Among women, behavior consistent with high-risk heterosexual activity was a more important predictor of HIV seroconversion than drug related activity. Incidence of HIV was double among women who reported an STD during the previous 6 months compared to that of women who had not. Condom use also was associated with a significantly increased risk among women. The effect of methadone maintenance on HIV serostatus among both males and females was negligible. There also was no significant difference in HIV seroconversion rates among either males or females between those who attended needle exchange programs and those who did not. This study highlights the overriding importance of sexual behavior as risk factors for HIV infection in IDUs, especially among women and men who have sex with men.
Some of the major data from this study has been illustrated graphically in “Notes” published by the National Institute on Drug Abuse (9).
Three of the above studies also measured the effect of methadone maintenance on HIV transmission but all failed to show a beneficial effect. (4)(5)(8).

Other Studies
In May 2001, the Canadian Bureau of HIV/AIDS, STD and TB’s Update Series published an article in Health Canada titled “ Risk Behaviors Among Injecting Drug Users in Canada” (10). The article is well written and takes into account risk behaviors other than needle sharing as factors in HIV transmission among IDUs such as prostitution both male and female and other risky sexual practices. Findings of studies of NEPs in Montreal, Ottawa, the Province of Quebec including Quebec City, Winnipeg, and Prince Albert in Saskatchewan were cited in the report. The following points are made at the outset:
1) The sharing of drug injection equipment remains unacceptably high among IDUs.
2) The level of reported, unprotected sexual intercourse is also high among IDUs.
3) Needle exchange programs alone are not sufficient to prevent HIV transmission among IDUs and should be complemented with a range of appropriate additional services.
The following statements are made in the article’s concluding comments and are repeated here verbatim: “When assessing the evidence on the effectiveness of needle exchange programs (NEPs) it is clearly important to understand who constitutes the comparison group in studies that have evaluated NEPs. Although NEPs are an integral part of Canada’s HIV prevention strategy for IDUs, exchange programs alone are likely not sufficient to prevent HIV transmission among drug users. NEPs need to be complemented by appropriate and accessible health and social services, as well as detoxification and drug treatment programs. Street involved youth and inmates are special
Subgroups of IDUs that should receive priority in HIV prevention policies and programs in Canada.”

Heroin Injectors and Sniffers
A more recent study compared the HIV prevalence rates among heroin sniffers, new heroin injectors and long term heroin injectors (11). The study population consisted of 900 heroin users equally divided into 3 groups; heroin sniffers, new heroin injectors and long-term heroin injectors. New heroin injectors were defined as those who had initiated injection during the previous four years, and long-term injectors were defined as those who had initiated injection prior to January 1, 1984, when it was assumed that the risks of infection with HIV were still unknown. The HIV prevalence rate among sniffers and new injectors was nearly the same, about 13%. The rate among long-term heroin injectors was almost double that, nearly 25%. The higher rate among long-term injectors was attributed to a maintained level of risky sexual activity over time as well as to the sharing of needles and drug paraphernalia. The authors attributed slightly more than half of the increased HIV prevalence among long-term IDU to high-risk injection behaviors, attributing the remainder to high-risk sexual activity. Race and ethnic group were important variables as determinants of the risk of infection. Hispanics were almost three times as likely to be HIV positive as non-Hispanic whites and African-Americans were over five times as likely to be infected as non-Hispanic whites. Men who had sex with men were at increased risk for infection with HIV compared to men who had sex with women only. A history of crack cocaine use among sniffers of heroin was also associated with higher rates of HIV infection. The authors stress that any interventions such as needle exchange must stress sexual risk as a component equal to that of injection.
Another report by the same authors studied HIV prevalence rates among heroin sniffers only with no history of drug injection (12). Here the HIV prevalence rate among men was 8.7% while among women the rate was more than double, 18.1%.
Both articles stressed the importance of sexual behavior in the high rates of HIV transmission among heroin addicts. As in the Baltimore study the higher HIV risk among women was probably attributable to selling or trading sex for drugs. It should be noted here that the latter two reports concern heroin use only. The Baltimore study included cocaine and other injected drugs as well as heroin (8).

Relevant Studies of Cocaine
A number of studies have been reported on the effects of cocaine, both crack and injected, on sexual behavior. One of these found that HIV antibody seroconversion among women was higher among crack users than non-crack or injection users (13). The strongest predictor of seroconversion was prostitution. The study reported that cocaine use in any form was associated with very high-risk heterosexual activity.
A second report cited the effects of drug counseling in four different treatment groups on sexual behavior of 487 cocaine dependant patients (14).. Most of the patients, 79%, were crack users. The most common HIV risks were having sex with multiple partners and unprotected sex. After six months of therapy cocaine use fell dramatically to an average 1 day per month and was associated with an average 40% reduction in HIV risk behavior across all treatment, gender and ethnic groups. Most of the reduction was a result of having fewer sexual partners and less unprotected sex.
Researchers at Harvard Medical School have reported that cocaine may impair the function of an important component of the immune system’s response to infection (15). In a controlled experiment 30 volunteers, including both sexes, with a history of cocaine use were given an injection of either saline or cocaine after 30 minutes exposure to an immune stimulant. A blood sample taken 4 hours later showed a marked (3-fold) diminution in the level of interleukin-6 (IL-6) in the blood of those injected with cocaine compared to those who received saline. IL-6 is a cytokine, an intercellular messenger, that acts primarily as an activator of inflammation and as a mediator of the acute-phase response to infection. Although, at present, this finding must be regarded as preliminary it points the way to further investigations into the effects of cocaine on the body’s ability to ward off infections. It could help to explain the higher HIV incidence that has been noted among users of cocaine.
A drug called vigabatrin (GVG) is about to be tested in large-scale clinical trials to determine whether it can serve as an effective treatment medication for cocaine abuse. The drug has been widely used abroad as a treatment for epilepsy. Although the trials will be time consuming because of the difficulty in recruiting enough cocaine users as participants the outlook for success is bright because of its known pharmacological properties.

Discussion
While part of the problem in the seven needle/syringe exchange studies cited here may have been a less than adequate number of needles and syringes supplied to the IDUs (the CDC has estimated that on average an IDU uses over 1000 sets a year) the main problem appears to have been the high level of risky sexual activity practiced by both male and female IDUs. The Baltimore study demonstrated that sexual activity was responsible for a major part of the HIV transmission occurring in both sexes especially in females and homosexual males (8). Similar findings were cited in the report published on-line by Health Canada (10). Both the studies of heroin users highlighted the strong role of sexual behavior in the transmission of HIV in both heroin injectors and sniffers (11)(12).
It is possible that needle/syringe exchange could have had some effect in reducing the rate of HIV transmission among participants but that effect was obscured by the numbers associated with high-risk sexual activity. The available evidence suggests that if that did happen the effect was modest at best. In two of the studies reviewed here the HIV prevalence rates were higher among users of the exchange than among non-users (1)(2). In two others there was no difference seen between users and non-users (5)(8). In two of the remaining studies there was no comparison of rates but substantial increases of HIV seroprevalence or that of the surrogate viruses, HBV and HCV was noted (6)(7). It is fair to say that NEP have not been measurably effective in limiting the spread of HIV, or of HBV and HCV in any of these studies. Some of them like Vancouver, Seattle, and Baltimore were operating in areas that lacked basic public health programs such as HIV name reporting and partner notification, programs usually used for control of sexually transmitted infections.

Other Needle/Syringe Exchange Studies
A number of other articles were found during this literature search which attempted to show an effect of NEP in reducing HIV transmission but whose results failed to provide hard evidence of that effect. One that presented seroprevalence data used an inappropriate statistical method in data analyses to achieve a significant result (24). None provided data on HIV seroprevalence or mortality among HIV infected IDU. Some of these studies show an impact by the NEPs on reducing risk behavior such as needle sharing among participants. This, however, is based primarily on self-reporting by individual IDU either on questionnaires or by face-to-face interviews. While interesting, this data lacks the probative effect of confirmation of the viral infection itself among the study participants. Those reports whose abstracts appeared most relevant are shown below under references with summarizing statements. Some of them were cited by the U.S. Department of Health and Human Services in the late 1990s as supportive of its recommendation that federal funds be used to support NEPs. Those are marked with an asterisk.

Comment:
Without intervention and treatment both heroin and cocaine addiction can last for years, for some, particularly heroin, a lifetime (16). In the large Baltimore study, the median duration of injection drug use was 14 years at the time of enrollment (8). Early in the course of this pandemic it seemed that needle/syringe exchange programs might provide an effective intervention in the growing epidemic of HIV disease among drug injectors but hard evidence to show this is lacking. Without credible evidence of efficacy, the provision of clean needles and syringes appears primarily to support the individual’s addiction and along with it, drug related high-risk sexual behavior.
There is no easy way to intervene in an epidemic that feeds on the injection of mind-altering drugs and their associated high-risk injecting and sexual behavior. Although injecting illicit drugs is harmful to both the user and to society, the HIV epidemic that was spawned by this practice has become a public health disaster. Since the beginning of the epidemic there have been nearly 210,000 reported cases of AIDS in injection drug users and 77,000 cases reported among their sexual contacts (17). Incomplete data for 2002 indicated there were nearly 11,000 new HIV/AIDS cases reported in the United States citing injection drug use as the source. A lesser number of cases among their contacts was also reported. Using very incomplete data, the CDC estimates that more than 54,000 cases of HIV infection, including AIDS, classified as IDU related, were alive at the end of 2002. A substantial proportion of all HIV infections in the United States were spun out of this continuing epidemic among IDU during the past 20 years.
Ideally, every individual who is HIV infected should receive evaluation and begin appropriate antiretroviral therapy. Therapy and/or monitoring will probably be necessary for the rest of the individual’s life. A large percentage of HIV infected IDU, however, fail to undergo appropriate treatment after their infection has been diagnosed (18)(19). In the large Vancouver Injection Drug Users Study only 35% of those infected with HIV are on antiretroviral therapy (20). Active injection drug use is usually incompatible with current antiretroviral therapies. Compliance with medication schedules is essential for adequate suppression of the virus and to minimize the risk of treatment failure due to drug resistance. Adherence to treatment schedules in future years is equally important for the same reason. Newly diagnosed HIV infected IDU will often need to undergo treatment for drug dependence before starting antiretroviral therapy. (21)(22)(23). Heroin injectors who accept treatment with methadone or buprenorphine are more likely to adhere to antiretroviral therapy than are cocaine injectors for whom there is as yet no medical treatment. Because of this a high percentage of cocaine dependent injectors and crack users who are HIV infected remain untreated. Access to health care is important and IDU who have health insurance coverage, for example, are more likely to undergo treatment both for their drug dependency and for their HIV infection. Untreated or improperly treated infections will continue to serve as a rich reservoir of HIV for transmission within communities of injection drug users.
The cumulative costs of the IDU HIV epidemic are already large and will continue to grow absent effective intervention. The energy and resources used for free- standing needle/syringe exchange programs (those that are not part of a comprehensive health care program) should be redirected to support the creation of badly needed additional drug treatment and rehabilitation services. The outreach performed by the NEPs should be replaced by outreach from substance abuse programs acting as liaison for drug treatment programs and linked to public health HIV prevention and care services. The messages conveyed with this outreach should include HIV risk reduction information including limiting the number of sexual partners and avoiding other high-risk sexual behavior. Existing public health disease prevention and control programs should be strengthened with active HIV surveillance in areas where injection drug use is known to be prevalent. IDU who become infected with HIV should be referred for appropriate treatment for their drug dependency as well as for antiretroviral therapy. Far from reducing harm, simply bringing needle/syringe exchange into this maelstrom only adds more fuel to the fire.

References:
1). Bruneau J, Lesotho F, Franco E, et al. High rates of HIV infection among injection drug users in needle exchange programs in Montreal: results of a cohort study. Am J Epidemiol. 1997; 146: 904-1002
2). Strathdee SA, Patrick DM, Currie SL, et al. Needle exchange is not enough: lessons from the Vancouver injecting drug use study. AIDS. 1997; 8: F56-65
3) Schechter M T, Strathdee SA, Cornelisse PG, et al. Do needle exchange programmes increase the spread of HIV among injection drug users?: an investigation of the Vancouver outbreak. AIDS. 1999 ; 13(6): F45-51
4). van Haastrecht HJ, van Ameijden ES, van den Hoek JA, et al. Predictors of mortality in the Amsterdam cohort of human immunodeficiency virus (HIV)-positive and HIV-negative drug users. Am J. Epidemiol 1996; 143: 380-91
5) Langendam MW, van Brussel GH, Coutinho RA, van Ameijden EJ. Methadone maintenance treatment modalities in relation to incidence of HIV: results of the Amsterdam cohort study. AIDS 1999; 13 (13): 1711-1716
6) Hagan H, McGough JP, Thiede H, et al. Syringe exchange and risk of infection with Hepatitis B and C viruses. Am J Epidemiol. 1999; 149: 203-218
7) Mansson AS, Moestrup T, Nordenfelt E, Widell A. Continued transmission of hepatitis B and C viruses, but no transmission of human immunodeficiency virus among intravenous drug users participating in a syringe/needle exchange program Scand J Infect Dis 2000; 32 (3): 253-256
8) Strathdee SA, Galai N, Safaiean M, et al. Sex differences in risk factors for HIV seroconversion among injection drug users: a 10-year perspective. Arch Intern Med. 2001; 161(10): 1281-128
9) Mathias R. High-risk sex is main factor in HIV infection for men and women who inject drugs. NIDA Notes 2002/2003; 17: no.2
10) Health Canada, Risk behaviors among injecting drug users in Canada, Bureau of HIV/AIDS, STD and TBUpdate Series-Index May 2001 On line at: http://www.hc-sc.gc.ca/
11) Chitwood DD, Comerford M, Sanchez J. Prevalence and risk factors for HIV among sniffers, short-term injectors and long term injectors of heroin. J Psychoactive Drugs 2003; 35 (4): 445-453
12) Sanchez J, Comerford M, Chitwood DD, et al. High risk sexual behaviours among heroin sniffers who have no history of injection drug use: implications for HIV risk prevention. AIDS Care. 2002; 14(3): 391-398
13) Webber MP, Schoenbaum EE. Heterosexual transmission of HIV infection in intravenous and non-intravenous drug using populations. Arch AIDS Res. 1991; 5(1-2): 45-47
14) Woody GE, Gallop R, Luborsky L, et al. HIV risk reduction in the National Institute of Drug Abuse Cocaine Collaborative Treatment Study. J Acquir Immune Defic Syndr. 2003; 33(1): 82-87
15) Halpern JH, Sholar MB, Glowacki J, et al. Diminished interleukin-6 response to proinflammatory challenge in men and women after intravenous cocaine administration. J Clin Endocrinol Metab. 2003; 88(3): 1188-1193
16) Hser Y, Hoffman V, Grella CE et al. A 33-year follow-up of narcotics addicts. Arch Gen Psychiarty. 2001; 58: 503-508
17) Centers for Disease Control and Prevention. HIV/AIDS Surveillance Report 2002. 14
18) Celentano DD, Galai N, Sethi AK, et al. Time to initiating highly active antiretroviral therapy among HIV-infected injection drug users. AIDS. 2001; 15(13): 1707-1715
19) Sherer R. Adherence and antiretroviral therapy in injection drug users. JAMA. 1998; 280: 567-568
20) Vancouver Drug Use Epidemiology. July 2003 on-line at http://www.cesa.ca/ccendu/pdf/report_vancouver_2003.pdf
21) Bouhnik AD, Chesney M, Carrieri P, et al. Nonadherence among HIV-infected injecting drug users: the impact of social instability. J Acquir Immune Defic Syndrom. 2002 ; 31 Suppl 3: S 149
22) Celentano DD, Vlahov D, Cohn S, et al. Self-reported antiretroviral therapy in injection drug users. JAMA. 1998; 280: 544-546
23) Strathdee SA, Palepu A, Cornelisee PGA, et al. Barriers to use of free antiretroviral therapy in injection users. JAMA. 1998; 280: 547-549

Other relevant reports with analysis or summarizing statements:
HHS citations marked by an asterisk

24) Des Jarlais DC, Marmor M, Paone D et al. Lancet 1996; 987-91 This study involved the use of meta-analysis to combine HIV incidence data from IDUs in three separate studies, two of which were in New York City and the third in high HIV prevalence areas (rates above 40%) in the New York metropolitan area and in Puerto Rico. These high prevalence areas were formed by the National AIDS Demonstration Research (NADR) cities. The groups differed markedly in size, racial composition, and in the frequency of drug injection at entry into the study. The third group, NADR high prevalence cities, had 1029 participants, none of whom were considered to have access to needle exchange programs, 64% were Latino/other ethnicity, and 44% were young, age less than 30. The other two groups were much smaller with 280 and 321 participants respectively, less than 10% were young (age less than 30) and only 36% were Latino/other. The distribution of whites among the three groups was even more disproportionate, In the first two groups 36% were white, non-Hispanic while in the third group (NADR cities) 8% were white, non-Hispanic. The proportion of African Americans in all three groups was similar, however. While the meta-analysis involving all three groups showed a protective effect of the needle exchange programs over a short span of time (from 6 to 10 months) most of this effect was due to the inclusion of the NADR cities as controls. The marked differences in the composition of the groups used in this study raises serious questions about the use of meta-analysis by the authors and the validity of the results.
25) Carr S, Goldberg D, Elliott L, et al. AIDS Care, 1996 Study shows that if multidisciplinary health and social services are provided to street sex workers at a time and place convenient to their work, the benefits are considerable.
26) Doherty MC, Garfein RS, Vlahov, et al. Am J Epidemiol, 1997* Study suggests that the initiation of NEPs does not result in an increase in the number of discarded needles in the street.
27) Gleghorn AA, Jones TS, Doherty MC, et al. J Acqir Immune Defic Syndr Hum Retrovirol, 1995 Current patterns of acquisition of needles and syringes in Baltimore are likely to increase HIV transmission. Increased availability and decriminalization of their possession could decrease the risk of injection-related HIV transmission.
28) Hahn JA, Vranizan KM, Moss AR. J Acquir Immune Defic Syndr Hum Retrovirol 1997 Among injectors who were interviewed before and after the opening of the needle exchanges in San Francisco, the number of sharing partners did not change among IDUs who attended or among IDUs who never attended the NEP. NEP should be considered prime sites for behavior-change interventions.
29) Hurley SF, Jolly DJ, Kaldor JM. Lancet 1997* Used published reports of HIV seroprevalence in IDUs in 81 cities around the world. 52 cities had no NEPs and 29 had NEP. The average annual change in seroprevalence was 11% lower in cities with NEPs. Despite the possibility of confounding variables, authors assert that the NEP may have led to a reduction in HIV incidence among IDUs.
30) Kaplan EH, Heimer RJ Acquir Immune Defic Syndr Hum Retrovirol. 1995* The article estimates the rate of new HIV infections among New Haven’s legal needle exchange program using syringe tracking and testing data. From May 1992 through August 1993 the data estimate that the incidence of new HIV infections among program participants was 1.63 new infections per 100 IDUs per year with a 95% confidence interval of 0-7.2
31) MacDonald M, Wodak AD, Ali R. et al. Med J Aust. 1997 The study used cross-sectional surveys of HIV seroprevalence in NEP in all Australian jurisdictions. HIV prevalence was 2.1% overall but much higher among homosexual men compared to heterosexual men (22.5% v. 0.7%.Thirty-one percent reported using a syringe after someone else during the preceding month. Cross-sectional surveys in NEP appear to be a practical method of monitoring rsk behavior and seroprevalence among IDUs
32) Paone D, Des Jarlais DC, Caloir S, et al. AIDS Educ Prev 1997 Using a survey of 2465 randomly selected NEP participants with regard to drug and sexual risk behavior between October 1992 and August 1994. Report compared those who continued risky behavior after joining an NEP with those who ceased risky behavior while using the exchange. Those continuing risky behavior were more likely to report passing on dirty syringes to other participants and to inject cocaine at least daily.
33) Schoenbaum EE, Hartel DM, Gourevitch MN. AIDS. 1996* Methadone-treated IDU with access to a needle exchange reduced injecting and needle sharing. This pattern of harm reduction, which began at least 4 years before the NEP opened, occurred in both those who did and did not utilize the needle exchange. Needle exchange, as a strategy to reduce injection-related harm, should not be viewed as discordant with methadone treatment.
34) Singer M, Himmelgreen D, Weeks MR, et al. Med Anthropol. 1997* The report presented findings (not included in abstract) from project COPE, a study of AIDS risk and risk prevention in a sample of 710 out-of-treatment IDUs in Hartford, CT. Findings are said to support the hypothesis that syringe exchange is an effective AIDS risk reduction modality.
35) Hagan H, Des Jarlais DC, Friedman SR, et al. Am J. Public Health, 1995 * This study’s results suggest that use of the needle exchange program led to a significant reduction in hepatitis B and hepatitis C in King county, WA and may have also prevented a substantial proportion of human immunodeficiency virus infections in injection drug users. These results were extended in a subsequent study by the authors which found no protective effect on either HBV or HCV transmission by the NEP (6).
36) Vlahov D, Junge B, Brookmeyer R. et al. J Acquir Immune Defic Syndr Hum Retrovirol. 1997* Study results show rapid and mostly large reductions in a variety of risky injection drug use behaviors among NEP participants. Findings are consistent with earlier reports showing an association between behavioral risk reduction and participation in needle exchange programs. Current patterns of acquisition of needles and syringes in Baltimore are likely to increase HIV transmission. Increased availability and decriminalization of their possession could decrease the risk of injection-related HIV transmission.
37) Gibson DR, Brand R, Anderson K, Kahn JG, Perales D, Guydish J. J. Acquir Immune Defic Syndr Hum Retrovirol. 2002. Report of a study of HIV risk behavior of clients and non-clients at a community syringe exchange program. The study recruited 338 untreated opiate addicted adult IDUs some of whom were clients of a local syringe exchange. At entry all participants reported injecting opiates at least once during the previous month. Participants were interviewed face to face for 20 to 30 minute initially. Seventy seven percent of the participants were reached for follow-up interviews a mean of 10.7 months after entry. HIV status was obtained by finger stick blood samples at entry Of these, only four (1.2%) were found positive for HIV. No figures are provided for serostatus at follow-up. Based on interview data the study found a significant reduction (two to six fold) in syringe sharing behavior during the period of follow-up among participants who utilized the syringe exchange.

 
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